\paperw5085 \margr0\margl0\ATXph16380 \plain \fs20 \f1 \fs22 England, and London in particular, suffered outbursts of bubonic plague in 1603, 1625 and again, \ATXnt901 with more
dire effects, in 1665-66\ATXnt0 , when around 70,000 to 100,000 people died. Although the initial carrier was the black rat, the spread of the disease was probably due to infected fleas passing from one human body to another.\par
